ABSTRACT
The IRCU of our hospital has increased its activity in the COVID-19 pandemic. The respiratory isolation condition has been an organizational challenge and has had a huge impact in the patient flow. Our IRCU has 3 subunits: nonCOVID (8 beds), COVID (up to 24 beds in open stay) and non-tested (8 beds). We have analysed the hospital activity register from November 2020 to April 2021, analysing the patient flow. For COVID IRCU admission criteria, a positive PCR with FiO2 > 0.50 with SatO2 <95%, RR > 25 and PaO2/FiO2 <250. We had 685 admissions: 52% in the COVID IRCU (average stay 6.82 days), 27.6% in the non-tested IRCU (AS 3.94 d) and 26.4% in the non-COVID IRCU (AS 6.32 d). A total of 43% admissions of the COVID-IRCU came from the Infectious Diseases Unit (IDU), 43.5% from the ED/other hospitals, and 1.12% from the ICU. Of the overall of COVID-IRCU, 29% required admission to the ICU and the mortality rate (MR) was 15.16%. A total of 40.7% admissions of non-COVID IRCU, ED 45.7%, and 13.6% the ICU. Of 6.4% patients required admission to the ICU (MR 6.4%). A total of 61.4% admissions of the non-tested IRCU, ED and 22.2% required admission to the ICU, with a 13.2% MR. The pandemic has highlighted the importance of the IRCU, reducing admissions and ICU stay. Our IRCU, maintains optimal respiratory isolation conditions in the non-tested IRCU, maintaining the normal activity in the non-COVID IRCU.
ABSTRACT
Coronavirus disease 2019 (COVID-19) pneumonia is associated with a high rate of pulmonary embolism (PE). In patients with contraindications for CT pulmonary angiography (CTPA) or non-diagnostic on CTPA, perfusion single photon emission computed tomography/computed tomography (Q-SPECT/CT) is a diagnosis option. The goal of this work is to develop an Intelligent Radiomic system for the detection of PE in COVID-19 patients from the analysis of Q-SPECT/CT scans. Our Intelligent Radiomic System for identification of patients with PE (with/without pneumonia) is based on a local analysis of SPECT-CT volumes that considers both CT and SPECT values for each volume point. We present an hybrid approach that uses radiomic features extracted from each scan as input to a siamese classification network trained to discriminate among 4 different types of tissue: no pneumonia without PE (control group), no pneumonia with PE, pneumonia without PE and pneumonia with PE. The proposed radiomic system has been tested on 133 patients, 63 with COVID-19 (26 with PE, 22 without PE, 15 indeterminate-PE) and 70 without COVID-19 (31 healthy/control, 39 with PE). The per-patient recall for the detection of COVID-19 pneumonia and COVID-19 pneumonia with PE was, respectively, 91% and 81% with an area under the receiver operating characteristic curves equal to 0.99 and 0.87.
ABSTRACT
INTRODUCTION: COVID-19 pneumonia is associated with a high rate of pulmonary embolism (PE) and its diagnosis can be changeling. In patients with contraindications for CT pulmonary angiography (CTPA) or nondiagnostic on CTPA, perfusion single photon emission computed tomography/computed tomography (Q-SPECT/CT) is a diagnosis option in patients with COVID-19 disease. Our aim was to develop an artificial intelligence (AI) model based on QSPECT/ CT images of patients during the COVID-19 pandemic which is able to classify lung lesions to optimize PE diagnosis. METHODS: Single center study with a prospective observational branch with patients who tested positive for COVID-19 and underwent a perfusion SPECT-CT study for diagnosis of PE, from April to September 2020. The second branch is retrospective, with patients in pre-pandemic period who underwent Q-SPECT/CT for diagnosis of PE from January to December 2018. For each patient, a Q-SPECT/CT based on intravenous administration of 6 mCi (222MBq) of 99mTC-macroaggregates of human-albumin (99mTC-MAA) was performed, with the subsequent tomoscintigraphy (SPECT) and a CT. The entire image pre-processing (volume exploration, segmentation analysis, registration analysis) was conducted with MATLAB. The final diagnosis for each patient and the different tissue type segments were analyzed and validated by two senior nuclear physicians. Our Intelligent Radiomic System for the identification of patients with PE (with or without pneumonia) is based on a local analysis of SPECT-CT volumes that considers both CT and SPECT values for each volume point. Volumes are first co-registered and their intensity is normalized in [0, 1] to account for differences due to acquisition. A support vector machine (SVM) model was trained to discriminate among 4 different types of tissue: no pneumonia without PE (control group), no pneumonia with PE, pneumonia without PE and pneumonia with PE. We followed a k-fold (with k=30) scheme for statistical analysis of results. RESULTS: We collected 133 patients, 63 in prospective branch (26 with PE, 22 without PE, 15 indeterminate- PE) and 70 in retrospective branch (31 healthy/control, 39 PE). Concerning the local analysis, for all cases we obtain an average sensitivity and positive predictive value over 92%. CONCLUSION: This study represents a first step towards a complete intelligent radiomic system to optimize the diagnosis of PE by Q-SPECT/CT. The capability to detect alterations in perfusion for COVID-19 pneumonia encourages developing a tool in the cloud for clinical use and further investigates if it can also predict long term complications.